Role of dendritic cells in immune dysfunction

Texas Medical Center NASA/Johnson Space Center, Cooperative Agreement Program NCC 9-36, Round 1 ... final report

Publisher: National Aeronautics and Space Administration, Publisher: National Technical Information Service, distributor in [Washington, DC, Springfield, Va

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  • Infectious diseases.,
  • Bioreactors.,
  • Cells (Biology),
  • Cancer.

Edition Notes

StatementCherylyn A. Savary, [principal investigator].
Series[NASA contractor report] -- NASA-113071., NASA contractor report -- NASA CR-113071.
ContributionsUnited States. National Aeronautics and Space Administration.
The Physical Object
Pagination1 v.
ID Numbers
Open LibraryOL15539463M

Title:Potential Role for Dendritic Cells in Endothelial Dysfunction, Diabetes and Cardiovascular Disease VOLUME: 23 ISSUE: 10 Author(s):Astrid Parenti*, Laura Pala, Sara Paccosi and Carlo Maria . Tumor Cell/Dendritic Cell Interactions and the Influence of Tumors on Dendritic Cell-mediated Anti-Tumor Immune Responses and Dendritic Cell-Based Tumor Immunotherapies a role for these cells as critical regulators of anti-tumor immune . Malaria causes significant morbidity worldwide and a vaccine is urgently required. Plasmodium infection causes considerable immune dysregulation, and elicitation of vaccine immunity remains challenging. Given the central role of dendritic cells . Dual role of natural and adaptive immunity in RCC. Innate immune cells (dendritic cells, macrophages, NK cells, neutrophils, and MDSCs) and adaptive immunity (B and T cells) in the tumor .

Immune mediators play a critical role in the pathogenesis and outcomes of a number of cardiac diseases. This review summarizes recent findings on the composition of the inflammatory infiltrate and the role of different types and subtypes of immune cells and their products in mediating cardiac dysfunction . The past decade has seen tremendous developments in novel cancer therapies through targeting immune-checkpoint molecules. However, since increasing the presentation of tumor antigens remains one of the major issues for eliciting a strong antitumor immune response, dendritic cells . Crucial to the role of dendritic cells (DCs) as immune sentinels is their capacity to interact with lymphocytes [].This interaction mediates bi-directional signaling; DCs activate T lymphocytes (both .   Natural killer cells (NKs) and dendritic cells (DCs) are key players in the immune system. Previous studies have shown that their cross-talk plays a central role in the NK functions in .

The diverse roles played by mitochondria in T-cell activation emphasizes the potential mechanisms by which aging-related mitochondrial decline may contribute to immune dysfunction. Following stimulation of the T-cell receptor, T-cells . The progression of multiple myeloma, a hematologic malignancy characterized by unregulated plasma cell growth, is associated with increasing innate and adaptive immune system dysfunction, notably in the T-cell . This comprehensive volume, written by experts in the field, is the first to address the biology of dendritic cells (DCs) in an integrated fashion, in the context of HIV infection and immunity. The book brings together the most recent information related to the biology of DCs and their role . The effector cells from the innate and adaptive immune systems play a crucial role in sepsis. Dendritic cells, in particular, serve as professional antigen presenting cells and are involved in the aberrant immune .

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Cancer immunotherapy. Dendritic cells (DCs) are antigen-presenting cells derived from bone marrow precursors and form a widely distributed cellular system throughout the body. DCs exert immune-surveillance for exogenous Cited by: 4.

Abstract: Dendritic cells (DC) are potent antigen presenting cells that display an extraordinary capacity to present antigen to naïve T‐cells and initiate primary immune responses. In the context of the lung and upper airway it is clear that DC play a key role in the regulation of adaptive immune.

Dendritic cells (DCs) were initially identified as potent antigen-presenting cells that play a key role in induction of the innate immune response. Further investigation revealed DCs Cited by: Get this from a library. Role of dendritic cells in immune dysfunction: Texas Medical Center NASA/Johnson Space Center, Cooperative Agreement Program NCCRound 1 final report.

Sepsis is a common complication of severe trauma, shock, infection, and major surgical operation, which can lead to septic shock and multiple organ dysfunction syndrome [].The immune system responds to injury by rapidly producing early and late inflammatory cytokines, by affecting maturation and differentiation of dendritic cells (DCs), and by suppressing T-cell.

Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells Cited by:   Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses.

As such, they are the master regulators of the immune response and serve this function by linking the microbial sensing features of the innate immune Cited by: IL-6 also plays an important role in acquired immune response to induce differentiation of activated B cells in to antibody (Ab)-producing cells and to prolong survival of plasmablasts, while it promotes the development of Th17 cells and follicular helper T cells by naïve T cells and inhibits the differentiation into regulatory T cells.

Dendritic cell dysfunction in patients with various cancers is documented and immunotherapy using dendritic Role of dendritic cells in immune dysfunction book in a range of GI cancers is described and discussed play a significant role in.

Through the release of inflammatory cytokines and expression of co-stimulatory molecules, and antigen presentation, innate immune cells such as dendritic cells can interact with CD4 T-cells and direct. Among the many cells of the immune system exerting important functions in the host response to neoplastic transformation, dendritic cells (DC) deserve a special attention, since these cells, which are an highly heterogeneous cell population present in the blood, in the lymphoid organs as well as in the tumor microenvironment, represent the major actors in linking innate and adaptive anti-cancer immunity.

Dendritic cells (DCs), named for their probing, ‘tree-like’ or dendritic shapes, are responsible for the initiation of adaptive immune responses and hence function as the ‘sentinels’ of the immune system.

Dendritic cells (DC) play a pivotal role in the tumor microenvironment (TME). As the primary antigen-presenting cells in the tumor, DCs modulate anti-tumor responses by regulating the magnitude and. Dendritic cells (DCs) are antigen-presenting cells with an emerging role in hepatic inflammation.

We postulated that DCs are important in the progression of NASH. We found that intrahepatic DCs. Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system.

Dendritic cells (DC) play a pivotal role in regulating immune responses by presenting antigens to naïve T lymphocytes, modulating Th1/Th2/Treg balance, producing numerous regulatory cytokines and. Dendritic cells (DCs) act as a bridge between innate and adoptive immunity.

They are widely distributed in various tissues and organs. Resident ocular DCs are found in the peripheral. Dendritic cells (DCs) play a crucial role in initiating immune responses against both foreign pathogens as well as tumors.

DCs also control the type, potency, and extent of T-cell responses. The unresponsiveness of the host immune system is one of the major mechanisms of tumor escape as well as an important factor that limits the success of cancer immunotherapy. Inadequate function of professional antigen presenting cells dendritic cells (DC) in cancer is one of the major elements of compromised anti-tumor immune.

Dendritic cells. These cells are effective APCs that migrate from the bone marrow into peripheral tissues. They are a pivotal link between the innate immune system and the adaptive immune system.

So-called because their surface membrane looks similar to the tree-like dendrites of neurones, dendritic cells are key in activating T-cells. Abstract Dendritic cells (DCs) are essential in immunity owing to their role in activating T cells, thereby promoting antitumor responses. Tumor cells, however, hijack the immune system, causing T cell.

NK cells play an important role in host immunity against cancer by exerting cytotoxicity and secreting a wide variety of cytokines to inhibit tumour progression. Their effector functions are regulated by the integration of opposing signals from activating and inhibitory receptors, which determine NK cell activity against tumour targets.

NK cell. Phenotype and function of human dendritic cell subsets. Characteristic phenotype, transcription factor requirements, Toll-like receptor (TLR) expression, cytoki. Title: Role of Dendritic Cells in HIV-Immunotherapy VOLUME: 8 ISSUE: 4 Author(s):Ellen Van Gulck, Viggo F.

Van Tendeloo, Zwi N. Berneman and Guido Vanham Affiliation:Institute of Tropical Medicine, NationalestraatB Antwerp, Belgium. Keywords:dendritic cells. Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment Clin Cancer Res.

May 1;22(9) doi: /CCR. "Dendritic Cells in Cancer," edited by Michael R. Shurin and Russell D. Salter, presents thorough analyses of the complex biology of the tumor-dendritic cell relationship, and offers insights into how. Immunomodulation by the spleen requires the synergistic action of splenic dendritic cells (DCs) and various immune cells, including T cells, B cells, and Treg cells.

DCs are the most important professional antigen-presenting cells. Gupta S (). Role of dendritic cells in innate and adaptive immune response in human aging.

Exp Gerontol, [] Chougnet CA, Thacker RI, Shehata HM, Hennies CM, Lehn MA, Lages CS, et al. Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction.

Subsequently, various studies have also reported the association of exosome-like structure with all types of immune cells, such as B and T lymphocytes, dendritic cells (DCs), natural killer (NK) cells, mast cells, macrophages, and thymocytes.

Exosomes derived from immune cells play an important role in regulating the immune. In addition, in the milieu of persistent antigen and inflammation within TME, the CTLs would enter an “exhausted” state, which contribute to the T cell dysfunction and tumor development [5,39]. (2) NK cells.

NK cells are also one important subset of tumor-antagonizing immune cells. Dendritic cells (DCs) orchestrate the initiation, programming, and regulation of anti-tumor immune responses.

Emerging evidence indicates that the tumor microenvironment (TME) .Background: Dopamine is responsible for inflammatory response and plays a role in the skin immune system by modulating T-cells, dendritic cells, and keratinocytes which increases skin inflammatory.